Sunday, August 26, 2007

Letter to A Friend !!!!

Your Friendship is very valuable to me,
Which is countless or rather priceless.....
You've always helped me in my troubled times....
You've always supported me when i was depressed.....
The caress of your true friendship,
Is what that brings a bliss in my life....
I thank the Almighty god for sending an Angel like you,
As my Friend.....
I've always looked upon you as a Friend Whom i can count on.....
I've looked up to you because you are
Caring, and
Your Beautiful inner self just makes me much more happy to be with you.....
Thank you for being you in that very special way.....
And above all you have given me a
Reason to Smile.....
And till my Last breath, I promise you that i will be your
'True Friend' .....

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Monday, August 20, 2007

The Other Side of Me!!!

K Here u can see the Other side of Me!! I ve acted in a Short Movie, Its about a Local Rural chap Kisen (played by me) , who comes to big city Mumbai , to fulfill his dreams, earn money be rich. The movie (if u understand) tries to show the struggles a person has to face in a new city, in the face of corruptions. Series of Disappointments can lead anyone to give in to illegal means of earning money....
Though it might sound like a very serious film, its not that serious. The actors make every possible efforts to keep u smiling.. :)
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How deep Is your Love !!!!

"How Deep Is Your Love"
Bee Gees - How Dee...

I know your eyes in the morning sun
I feel you touch me in the pouring rain
And the moment that you wander far from me
I wanna feel you in my arms again

And you come to me on a summer breeze
Keep me warm in your love
Then you softly leave
And it's me you need to show

How deep is your love?
How deep is your love?
I really meant to learn
Cos we're living in a world of fools
Breaking us down when they
All should let us be.

I believe in you
You know the door to my very soul
You're the light in my deepest, darkest hour
My savior when I fall

And you may not think I care for you
When you know down inside
That I really do

How deep is your love?
How deep is your love?
I really meant to learn
Cos we're living in a world of fools
Breaking us down when they
All should let us be.

Perhaps the most Beautiful Love song ever... I mean listen to the lyrics, Its just epitomizes those feelings when ure in Love....
Some say True Love , u experience only once in your lifetime....
Some say Love is blind....
Some say Everything is fair in Love and war....
Some say Dont Fall in Love, Rise in Love....

What crap. I say Stop falling in Love and get on with you life....
Nowadays All the Love is reduced to mere compromise. After all Love doesnt give everything in life, U need to be more compatible wid a person to live together....
There are people Who still believe in true Love n all... I dont, We live in a fast paced World, Its better to be practical than living in a Dream World!!
Better Love a person, Wid whom u r compatible.... And i bet u wont be disappointed in Life...
I might seem like a person whos just had a failure in a relationship, n out of frustration im writing all this, but this is the real world!!!
Its common Human tendency, we fear to face the practical truths of life... Theres always Hope that things will work out. In bad times, we fill things will get better... But whether it gets better or worse, no one can tell. Rather than waiting and hoping for things to happen, U just have to to suck it up at that moment and move on in life...

K i started out wid a Beautiful Song , and ended up like a sadist column...
So just enjoy he song , Enjoy those special moments to the fullest... or else Like Shahrukh Khan says, " Kya Pata Kal Ho naa Ho !!! "
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Wednesday, August 15, 2007

60 Years of Independence !! How We've Fared !!

Today is 15th August. We celebrate 60 years of freedom since 1947.
Its a great feeling that we have come a long way in these 60 years.
The things that have improved is our Economy which is on a rise. India's GDP grew by 9.4% in 2006-07 as compared to 9.0% in 2005-06 , the per capita income growth rate is estimated to be around 8.4% for 2006-07, Literacy rate though not much has still increased, Employment rate is increased. Many Multinational Companies see India as a potential place for their Growth and i wont disagree. The roads have improved, Telecommunication network has improved..
The youth are slowly starting to realise their responsibility to the nation, At least i do , wanna make a difference for my country, and Politics is the place to be. As someone has rightly said, ' To Change the System, you have to be in the System'.
The problems to tackle are India's exploding population, which is about 1.12 billion as of now, with more population, u need more infrastructure. One thing is still very much prevalent is Poverty, feel bad when i see young kids begging at signals n road junctions, They must be studying in some school. But thats the way it is now in India, The Rich get richer and the Poor get poorer. Where there is all the latest amenities and gadgets in the big cities, People in the rural area get to enjoy only about 3-4 hrs of electricity n water supply everyday. Medical facilities are in a boom in the big cities, and in scarcity in rural areas. The Rural development scheme by the government is not very much functional.
As the Economy is growing so is Corruption, Everyone wants to be rich. Corruption has to be dealt strictly, only then there would be some multifaceted progress of the country...
India's Test victory against India, and release of Indian women's Hockey based movie 'Chak De India' ,couldn't have come at a better time, on the eve of 60 years of Independence.
Whatever may be the condition of my country, but i love my country, and i would strive for betterment of my country..
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India's Test Series Victory in England in Pictures

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Monday, August 13, 2007

A Passionate night

It was raining that day.. I was looking from my window , was waiting for her. She had called me up n said she'l come in bout an hour. It was raining very heavily that day , So was worried if she'l be able reach safely as she was very new to the city.
Just then i heard an Autorichshaw coming inside my building compound and there she was, as beautiful as ever, She was wearing a blue dress, wid an umbrella in hand n struggling to take sum money from her purse to give it to the driver. While doing so her umbrella started sliding down from her shoulders, n fell down. Now she was totally wet. With all despair n anguish, she entered my wing, cursing the rain, as if her whole life was destroyed by those few rain drops which fell on her. Well i was enjoying every bit of the ordeal.
She rang the bell n came in. I cud see the happiness in her face seeing me after a long time. ya i was happy to see her too.. I introduced her to my parents , my bros and we started chatting. We talked n talked n talked bout all those old days, those wonderful experiences we had together. As we started talking, i dint realise it was quite late and it was dinner time. We had our dinner which by the way was very delicious as usual. My mom cooks sum awesome food.
k now it was time to to leave. As it was late in the nite, i had to accompany her till the bus stop. we said bye to my parents. we started off. was gonna drop her in a local bus, so we had to walk a certain distance to reach the bus stop. It was really nice weather windy , cool, and absolutely romantic. As we started walking, she started blabbering as usual. i looked at her. Man o' man she was looking so pretty, her beautiful eyes , her wavy, silky hair moved wid the wind as if they were singing wid the wind, her smile seemed worth more than a million dollars that day. I dont know what was happening to me that day. I never looked at her in that manner, she was a friend. I kept reminding my self the same thing again n again... as there were weird thoughts coming onto my mind, wanted to hold her near me and kiss her passionately.
In the mean time, it started raining very heavily, i had forgot my umbrella, n incidentally her umbrella refused to open. damn!!! we both were getting wet, i saw a small shed at the side of the road. we had to run quite a distance to reach there. Strangely there was not a single vehicle on that road , not even an autorickshaw, as if sumtin was meant to happen.
i handed her my Handkerchief, to wipe her face as we both were completely wet. Damn she looked more beautiful n sexy in her wet clothes, I cud see drops of water running down her cheeks, her lips. I coudnt resist myself. I decided i'l make a move. i held her wid both my hands strongly, looked in her eyes, we were both staring at each other passionately, well dont know bout her, but atleast i was. I moved closer to her. I could literally hear her heartbeats getting faster, and mine was too. I moved more closer. i dint know whether i was doing the right thing or not. I just knew that i have to kiss her.
 I had seen in the movie Hitch, in which Will Smith says, " The secret to a good kiss is to go 90% towards the gal and wait for the gal to move other 10 % towards you and wait as long as it takes". I thought the time has come to implement these tips in real life. 
As i stood close to her, i bent down towards her , well yeah 90% towards her n waiting for a while, and guess what she also started moving towards me. Wow i thought ive hit a jackpot today. As we our lips came closer n closer , just before the kiss , i heard a very loud noise and it was really painful to my ears. It was my morning 'ALARM'.
"Damn it!!! it was a dream." I screamed in disgust and went to sleep again....

MORAL OF THE STORY : Never go 90... go direct 100 :)
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Friday, August 10, 2007

An Alternative to Stem Cells for Treating Chronic Brain diseases!

With ethical issues concerning use of discarded embryos and technical problems hindering development of stem cell therapies, scientists in Korea are reporting the first successful use of a drug-like molecule to transform human muscle cells into nerve cells. This advance could lead to new treatments for stroke, Alzheimer's disease, Parkinson's disease and other neurological disorders.

In the study, Injae Shin and colleagues point out that stem cell research shows promise for repairing or replacing damaged nerve cells to treat such diseases. However, many barriers hinder efforts to move those therapies from lab to clinic. The use of "small molecules" -- compounds that include most drugs -- to generate new nerve cells from easily available cells or tissues would provide a more convenient and attractive approach to stem cell therapies, the new study notes.

The researchers exposed immature mouse muscle cells (myoblasts) growing in laboratory cell cultures to neurodazine, a synthetic small molecule. After one week, 40-50 percent of the myoblasts were transformed into cells that resembled both the structure and function of nerve cells, including expression of neuron-specific proteins. Additional studies showed a similar transformation in a group of human skeletal muscle cells that were exposed to the same chemical for several days, they add.

"In conclusion, we have developed the first small molecule that can induce neurogenesis of non-pluripotent myoblasts and the cells derived from mature, human skeletal muscle," the report states. "These studies build upon recent research illustrating the value of chemical approaches for providing tools that differentiate lineage-committed cells into other cell types."

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Wednesday, August 08, 2007

Advances in Telomere Therapy Outstrip Stem Cell Therapy Without Raising Ethical Concerns

The debate over stem cell research and its ethical and moral implications continues to rage on even though there seems to be an alternative to stem cell therapy that is decidedly better.
Among politicians in Washington an effort is being made to block scientists from using embryonic stem cells in research, which is where the future of stem cell therapy seems to be headed, despite the promises such research holds for curing cancer and other serious diseases. Because embryos from which stem cells are cultivated necessarily die, research in this direction has come under fire as unnecessarily killing potential lives.
Regardless of the ethics and morality behind embryonic stem cell research, both sides of the debate have ignored emerging technologies that are likely to make embryonic stem cell research a mute point. Nanotechnologies involving chromosomal telomeres, such as those acquired and developed by Rancho Cordova, California-based Telomolecular, can achieve everything that stem cell therapies achieve but without many of the drawbacks.
Telomeres are protein compounds that act like caps on the ends of chromosomes and make sure that the DNA replication process ends the way it’s supposed to when a cell divides. But every time a cell divides the telomeres shorten and eventually they become exhausted. Telomere exhaustion has been linked with numerous age-related diseases and with cancer. Stem cell therapy attempts to address this problem by growing new tissue with renewed telomeres in place of the tissue with exhausted telomeres. But stem cell therapy can lead to development of cancerous or abnormal tissues.
Telomere therapy, combined with Notch 1 therapy (used in treating regeneration abnormalities in non-dividing cells), regenerates exhausted tissues comprehensively and does not just grow new tissue in the presence of old tissue. This results in a significantly lower chance of growing cancerous and abnormal cells. Additionally, telomere therapy can be administered via non-invasive drugs to treat disease in targeted locations, which is not true of stem cell therapies.
“By combining telomere therapy with Notch 1 therapy we can accomplish everything that stem cell therapy can,” said Telomolecular chief executive officer Matthew A. Sarad. “Plus these technologies can be administered in sensible, non-invasive ways.”
Telomolecular is using its proprietary technologies in research that shows strong promise of treating and preventing cancer, reversing age-related diseases, and regenerating bone and other tissues. The treatments being developed by Telomolecular do not involve the cultivation of stem cells, therefore ethical and moral considerations linked to embryonic stem cell research do not apply to the research being done by Telomolecular and other biotechnology firms investigating telomere therapies.
Without a doubt, the promise of combating cancer and other diseases with telomere therapy outweighs the moderate success of stem cell therapies. It’s time that scientists and politicians turn their attention to this developing technology and forget the ethics-challenged hope of embryonic stem cell research.

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Adult Stem Cell Regulation - New Theory !!

Forsyth Institute scientists have discovered an important mechanism for controlling the behavior of adult stem cells. Research with the flatworm, planaria, found a novel role for the proteins involved in cell-to-cell communication. This work has the potential to help scientists understand the nature of the messages that control stem cell regulation -- such as the message that maintain and tells a stem cell to specialize and to become part of an organ e.g.: liver or skin.

In recent years, planarians have been recognized as a great model system to molecularly dissect conserved stem cell regulatory mechanisms in vivo. Planarians have powerful regeneration capability that makes them ideal for studying this process. The Forsyth team uses planarians and other animal models to study development and regeneration.

The Forsyth team will publish this research in the August 16 issue of Development. According to the paper's lead author, Nestor J. Oviedo, a postdoctoral fellow in the Forsyth Center for Regenerative and Developmental Biology, this work, highlighting the importance of direct cell-cell transfer of small molecules between stem cells and their neighbors, provides an important roadmap for learning about regeneration. "These findings suggest that similar mechanisms may be extraordinarily relevant for controlling the behavior of migratory, plastic cells. Further analysis in both planarians and in vertebrates will provide crucial opportunities for understanding what drives stem cell behavior and may help medical science identify novel therapeutic targets."

The Forsyth team previously found that communication through gap-junctions (microscopic tunnels directly linking neighboring cells) controls the left-right asymmetric positioning of the internal organs during embryonic development. In this study, they turned to the role of gap junctional signals as regulators of adult stem cells in repair of injury.

Drs. Oviedo and Levin focused on direct cell-cell transfer of small molecules and ions as crucial signals that determine behavior of adult stem cells in vivo. They showed that when one of many specific gap junction channel types was abolished, the adult stem cell pool disappeared along with the regenerative capabilities, suggesting that gap junction-permeable signals are necessary to maintain stem cell state and tissue regeneration. This research demonstrates a novel role for gap-junction proteins and suggest gap junction-mediated signaling as a new and tractable control point for adult, somatic cell regulation

Most recent work in the stem cell field has focused on the secreted protein factors that control embryonic stem cell differentiation. However, no specific gap junction protein had been functionally linked to adult/somatic stem cell behavior in vivo or to organ regeneration. This work demonstrates that gap junction channels providing direct cell-to-cell communication are a critical component for development and normal physiology.
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Monday, August 06, 2007

Viralink - New way to increase back links!!

———copy and paste the Viralink and instructions below this line———

Below is a matrix of 120 stars, I have already added a link to my blog onto one of the stars, all you need to do is copy and paste the grid into your blog and add your own link to one of the other spare stars, and tell others to do the same!



When I receive a ping back once you have added the Viralink to your site I will add your link to this grid, and each person who copies the grid from here will also link to your site!

No Porn Sites
Only 1 link per person (i.e don't hog the viralink!)
Please don't tamper with other peoples url's

———copy and paste the Viralink and instructions above this line———

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Sunday, August 05, 2007

Wonderful Quotes!!!

" God Says, Do what your Heart says, and use your Mind to make it happen"

"The highest courage is to dare to appear to be what one is."

"If suffer we must, let's suffer on the heights."

"But in the end one needs more courage to live than to kill himself."

"When someone does something good, applaud! You will make two people happy."

"The art of being wise is the art of knowing what to overlook."

"The truth is that there is nothing noble in being superior to somebody else. The only real nobility is in being superior to your former self."

"I know God will not give me anything I can't handle. I just wish that He didn't trust me so much."

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Wednesday, August 01, 2007

Hope for new Parkinsons' Therapy

Scientists have discovered a protein which may help to slow, or even reverse symptoms of Parkinson's disease.
Parkinson's destroys nerve cells that produce the brain chemical dopamine, causing movement and balance problems.
Finnish researchers found the new molecule can prevent degeneration of these cells - and help damaged cells start to recover.
Their paper, featured in Nature, showed symptoms eased in rats given injections of the protein.
Our new protein has great potential to be developed as drug for Parkinson's disease Dr Mart Saarma University of Helsinki
Current anti-Parkinson's drugs do not stop nerve cells from degenerating and dying, and their effects can be patchy and short-lived.
The researchers, from the University of Helsinki, believe the new molecule - dubbed conserved dopamine neurotrophic factor (CDNF) - has great potential as a treatment.
Previous research has centred on another protein - GDNF - which some research had suggested could improve symptoms in Parkinson's patients.
However, other studies have thrown doubt over the effect of the protein - and raised serious safety issues.
The Helsinki team decided to search for related proteins - known as growth factors - which worked in a similar way, but were likely to be better tolerated.
They found that CDNF, unlike other similar growth factors, was specific to brain nerve cells.
Experiments were carried out on rats bred to show symptoms similar to Parkinson's.
In tests, CDNF protected 96% of nerve cells in the brains of the animals from degeneration.
Delay in treatment
To test whether the protein could also help repair damage in nerve cells the researchers also waited a month before treating some of the animals to allow Parkinson's symptoms to really take hold.
This was designed to mimic the situation in human patients, who may already have lost 70% of their dopamine-producing nerve cells by the time they seek treatment.
Following treatment 58% of the dopamine-producing nerve cells were left alive, compared with just 26% in animals who did not receive the protein.
Lead researcher Dr Mart Saarma said: "Our new protein has great potential to be developed as drug for Parkinson's disease, but we need to do more animal experiments and also toxicology studies before we can start clinical trials."
Dr Kieran Breen, of the Parkinson's Disease Society, said the research was still at a very early stage.
"What is interesting is that the protein shows similar neuro-protective actions to GDNF which indicates that this general type of drug may be useful in the future for developing new therapies for treating Parkinson's.
"However, while GDNF showed some benefits in early clinical trials, larger trials showed side effects, which led to it being withdrawn. It is therefore too early to predict the therapeutic potential of CDNF."
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Did u knw bout Twins???

K i myself being a Twin.. I thght i'l share sum info bout twins...

1st of all There are 2 types of twins 1) Identical 2) Fraternal

Identical Twins

Identical Twins happen when a single fertilized egg splits usually one to fourteen days after conception. Identical twins are genetically alike.They have the same chromosomes and usually have a lot of the same physical features but are not totally the same. Each twin is an individual and has different traits of his own. Identical twins are the same sex, the same blood type and have the same hair and eye, color, same nose, ear and lip shapes.

The identical birth rate is approximately 4/1000 births and is thought to be an accident of nature.Chances of having two sets of identical twins is one in 70,000.

Identical twins spend a lot of time together and are usually each other's best friend. Although they like other people, their twin is the person they usually choose to be with, especially when they are young. They do not like to be apart. Identicals usually have their own private language and have the ability to do the same in the same activities. They also enjoy each others company because they usually have the same interests.

Identical twins usually care for one another more deeply than fraternals. This is because of the special bond between them that grew while they were inside their mother. After age 9 or 10, identicals usually choose to form their own identities.

Fraternal Twins

Fraternal Twins are the most common type of twins. They are the result of the union of two eggs and two sperm. They may not look alike and can be different sexes. Fraternal twins can be conceived at separate times and can have different fathers.The tendency to conceive fraternal twins seems to be heredity. Some studies show higher incidence where there is a history of twins on the mothers' side of the family. About two-thirds of all twins are fraternal.

Opposite-sex twins make up one-third of the twin population, about one in 240 births. Boy/girl twins develop as differently as single birth children from the time of conception. Boys are usually heavier and longer than girls both before and after birth. Growth is faster in boys than girls until about 7 months of age, at which time females begin to grow faster until about the age of 4 years. Girls, on the average, tend to sit, crawl and walk earlier than boys. Boys show earlier visual skills while girls show greater talking skills.

While Fraternal twins do not usually develop the closeness and psychological interdependence that identical twins do, they do develop that " special bond" that all twins are known for.

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